Treatment With Anti–Tumor Necrosis Factor Biologic Agents in Human T Lymphotropic Virus Type I–Positive Patients With Rheumatoid Arthritis. Issue 5 (May 2014)

• Record Type: Journal Article
• Authors: Umekita, Kunihiko; Hidaka, Toshihiko; Miyauchi, Shunichi; Ueno, Shiro; Kubo, Kazuyoshi; Takajo, Ichiro; Hashiba, Yayoi; Kai, Yasufumi; Nagatomo, Yasuhiro; Okayama, Akihiko
• Is Part Of: Arthritis care & research. Volume 66:Issue 5(2014:May)
• Page Start: 788
• Page End: 792
• Publication Date: 2014-05
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.22205
• Languages: English
• ISSNs: 2151-464X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acr22205-sec-0001" sec-type="section"> <title>Objective</title> <p>To investigate the response to and safety of anti–tumor necrosis factor (anti‐TNF) therapy in human T lymphotropic virus type I (HTLV‐I)–positive patients with rheumatoid arthritis (RA).</p> </sec> <sec id="acr22205-sec-0002" sec-type="section"> <title>Methods</title> <p>Therapeutic response was evaluated in 10 HTLV‐I–positive and 20 HTLV‐I–negative patients with RA (sex and age matched) at 3 months after the beginning of anti‐TNF therapy using the European League Against Rheumatism improvement criteria. As secondary end points, the discontinuation rate of anti‐TNF therapy and its safety, especially the development of adult T cell leukemia (ATL), were evaluated over a 2‐year period.</p> </sec> <sec id="acr22205-sec-0003" sec-type="section"> <title>Results</title> <p>Significantly higher baseline levels of C‐reactive protein (CRP) were observed in HTLV‐I–positive patients than in HTLV‐I–negative patients (<italic>P</italic> = 0.0003). The response rate to anti‐TNF therapy was lower in HTLV‐I–positive patients than in HTLV‐I–negative patients. The median CRP level, erythrocyte sedimentation rate, and Disease Activity Score in 28 joints at 3 months after anti‐TNF treatment in HTLV‐I–positive patients were significantly higher than in HTLV‐I–negative patients (<italic>P</italic> = 0.003, <italic>P</italic> = 0.03, and <italic>P</italic> = 0.003, respectively). The discontinuation rate due to insufficient response was significantly higher in HTLV‐I–positive patients than in HTLV‐I–negative patients (<italic>P</italic> = 0.013). During the 2‐year observation period, no patients developed ATL.</p> </sec> <sec id="acr22205-sec-0004" sec-type="section"> <title>Conclusion</title> <p>These data suggest that HTLV‐I–positive patients with RA had higher inflammation and greater resistance to anti‐TNF treatment than HTLV‐I–negative patients. Further study is necessary to determine whether HTLV‐I infection should be measured when anti‐TNF agents are administered to patients with RA, especially in areas were HTLV‐I is endemic.</p> </sec> </abstract>