Clinical Utility of Serum Cystatin C in Predicting Coronary Artery Disease in Patients Without Chronic Kidney Disease. Issue 3 (29th January 2014)

• Record Type: Journal Article
• Authors: Dandana, Azza; Gammoudi, Imen; Chalghoum, Abdelkader; Chahed, Hinda; Addad, Faouzi; Ferchichi, Salima; Miled, Abdelhedi
• Is Part Of: Journal of clinical laboratory analysis. Volume 28:Issue 3(2014:May)
• Page Start: 191
• Page End: 197
• Publication Date: 2014-01-29
• Subjects: Diagnosis, Laboratory -- Periodicals; Medical laboratory technology -- Periodicals; 616
• DOI: 10.1002/jcla.21665
• Languages: English
• ISSNs: 0887-8013

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jcla21665-sec-0010" sec-type="section"> <title>Background</title> <p>Cystatin C has been proposed as a novel marker of renal function and predictor of cardiovascular risk. The aim of this study was to investigate the role of cystatin C level as a predictor of cardiovascular events in patients with coronary artery disease (CAD).</p> </sec> <sec id="jcla21665-sec-0020" sec-type="section"> <title>Methods</title> <p>Three hundred and five coronary artery patients were included in this study. Serum cystatin C levels, high‐sensitive C‐reactive protein (hs‐CRP), and oxidative stress were measured. Estimated glomerular filtration rate (eGFR) and the CAD severity score were calculated.</p> </sec> <sec id="jcla21665-sec-0030" sec-type="section"> <title>Results</title> <p>Cystatin C was correlated with the CAD severity score (<italic>r</italic> = 0.631, <italic>P</italic> < 0.0001) and was significantly elevated in the CAD severity score >50. Every 0.1 mg/l increase in cystatin C, 2 mg/l increase in hs‐CRP, 0.2 mmol/l decrease in high‐density lipoprotein cholesterol, 13.7 ml/min decrease in eGFR, and 1.51 μmol/l increase in homocysteine caused a 34, 12, 5, and 22% increase in the risk of having CAD, respectively.</p> </sec> <sec id="jcla21665-sec-0040" sec-type="section"> <title>Conclusion</title> <p>Cystatin C could be a useful laboratory biochemical marker in predicting the severity of CAD. Cystatin C is associated with biochemical atherosclerosis markers such as CRP and homocysteine.</p> </sec> </abstract>