Functionalizing Designer DNA Crystals with a Triple‐Helical Veneer1. (11th March 2014)

• Record Type: Journal Article
• Authors: Rusling, David A.; Chandrasekaran, Arun Richard; Ohayon, Yoel P.; Brown, Tom; Fox, Keith R.; Sha, Ruojie; Mao, Chengde; Seeman, Nadrian C.
• Is Part Of: Angewandte Chemie. Volume 126:Number 15(2014)
• Page Start: 4060
• Page End: 4063
• Publication Date: 2014-03-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201309914
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>DNA is a very useful molecule for the programmed self‐assembly of 2D and 3D nanoscale objects.<xref ref-type="link" rid="bib1">1</xref> The design of these structures exploits Watson–Crick hybridization and strand exchange to stitch linear duplexes into finite assemblies.<xref ref-type="link" rid="bib2">2</xref>–<xref ref-type="link" rid="bib4">4</xref> The dimensions of these complexes can be increased by over five orders of magnitude through self‐assembly of cohesive single‐stranded segments (sticky ends).<xref ref-type="link" rid="bib5">5</xref>, <xref ref-type="link" rid="bib6">6</xref> Methods that exploit the sequence addressability of DNA nanostructures will enable the programmable positioning of components in 2D and 3D space, offering applications such as the organization of nanoelectronics, <xref ref-type="link" rid="bib7">7</xref> the direction of biological cascades, <xref ref-type="link" rid="bib8">8</xref> and the structure determination of periodically positioned molecules by X‐ray diffraction.<xref ref-type="link" rid="bib9">9</xref> To this end we present a macroscopic 3D crystal based on the 3‐fold rotationally symmetric tensegrity triangle<xref ref-type="link" rid="bib3">3</xref>, <xref ref-type="link" rid="bib6">6</xref> that can be functionalized by a triplex‐forming oligonucleotide on each of its helical edges.</p> </abstract>