Neonatal leukemoid reaction associated with Candida albicans chorioamnionitis. Issue 2 (April 2014)

• Record Type: Journal Article
• Authors: Iwatani, Sota; Mizobuchi, Masami; Sofue, Toshiki; Tanaka, Satoshi; Sakai, Hitomi; Yoshimoto, Seiji; Nakao, Hideto
• Is Part Of: Pediatrics international. Volume 56:Issue 2(2014)
• Page Start: 277
• Page End: 279
• Publication Date: 2014-04
• Subjects: Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.12259
• Languages: English
• ISSNs: 1328-8067

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Chorioamnionitis due to <italic>Candida</italic> species is relatively rare, despite the high prevalence (20–25%) of <italic>Candida</italic> vulvovaginitis during pregnancy. We describe a case of neonatal leukemoid reaction (NLR) associated with <italic>Candida albicans</italic> chorioamnionitis. A male infant was born at 31 weeks' gestation and weighed 1864 g. Laboratory tests at birth indicated marked leukocytosis (i.e. total leukocyte count 89.8 × 10⁹/L including 66% polymorphonuclear leukocytes and 15% band forms). Samples of the infant's pharyngeal mucus and tracheal aspirate were positive for <italic>Candida albicans</italic>. On further histopathology of the placenta, <italic>C. albicans</italic> mycelia had invaded the placenta, chorioamniotic membrane, and umbilical cord. Although it is not very common, <italic>C. albicans</italic> chorioamnionitis should be considered in preterm infants with NLR.</p> </abstract>