Change in Inflammatory Markers and Cognitive Status in the Oldest‐Old Women from the Study of Osteoporotic Fractures. Issue 4 (2nd April 2014)

• Record Type: Journal Article
• Authors: Metti, Andrea L.; Yaffe, Kristine; Boudreau, Robert M.; Ganguli, Mary; Lopez, Oscar L.; Stone, Katie L.; Cauley, Jane A.
• Is Part Of: Journal of the American Geriatrics Society. Volume 62:Issue 4(2014:Apr.)
• Page Start: 662
• Page End: 666
• Publication Date: 2014-04-02
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.12739
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs12739-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs12739-sec-0001" sec-type="section"> <title>Objectives</title> <p>To determine the association between interleukin‐6 (IL‐6), IL‐6 soluble receptor (sR), and soluble tumor necrosis factor receptor‐1 (sTNF‐R1) and cognitive status in the oldest‐old women.</p> </sec> <sec id="jgs12739-sec-0002" sec-type="section"> <title>Design</title> <p>Twenty‐year longitudinal cohort study.</p> </sec> <sec id="jgs12739-sec-0003" sec-type="section"> <title>Setting</title> <p>Four clinical sites in the United States.</p> </sec> <sec id="jgs12739-sec-0004" sec-type="section"> <title>Participants</title> <p>Women from the Study of Osteoporotic Fractures (N = 905; mean age 88.3 ± 2.8 at cognitive status adjudication).</p> </sec> <sec id="jgs12739-sec-0005" sec-type="section"> <title>Measurements</title> <p>At Year 20, cognitive status was adjudicated as normal, mild cognitive impairment (MCI), or dementia. Inflammatory markers were measured from blood serum at Years 10 and 16 in a random sample of women.</p> </sec> <sec id="jgs12739-sec-0006" sec-type="section"> <title>Results</title> <p>Over 10 years, 199 (22.0%) women developed MCI and 145 (16.0%) dementia. There were no significant associations between IL‐6 or sTNF‐R1 and cognitive status. High IL‐6‐sR (≥37, 401.36 pg/mL, highest tertile) at Year 16 was significantly associated with lower risk of dementia (odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.30–0.97) than in women with lower levels (<37, 401.36 pg/mL, lower two tertiles). Women with high IL‐6‐sR at both time points (OR = 0.39, 95% CI = 0.17–0.89) or who transitioned to a high level (OR = 0.35, 95% CI = 0.14–0.88) had a lower risk of dementia.</p> </sec> <sec id="jgs12739-sec-0007" sec-type="section"> <title>Conclusion</title> <p>In this cohort of white, high‐functioning oldest‐old women, a consistently high or an increasing level of IL‐6‐sR was associated with lower risk of dementia. Compared with other studies of younger‐old adults, this suggests that the effect of inflammation on dementia may differ in younger‐old and the oldest‐old individuals. Understanding these differences will be crucial in interpreting results from ongoing clinical trials and in targeting therapeutic strategies to the oldest‐old individuals.</p> </sec> </abstract>