Epidemiology of human adenovirus and molecular characterization of human adenovirus 55 in China, 2009–2012. Issue 3 (28th January 2014)

• Record Type: Journal Article
• Authors: Lu, Qing‐Bin; Tong, Yi‐Gang; Wo, Ying; Wang, Hong‐Yu; Liu, En‐Mei; Gray, Gregory C.; Liu, Wei; Cao, Wu‐Chun
• Is Part Of: Influenza and other respiratory viruses. Volume 8:Issue 3(2014:May)
• Page Start: 302
• Page End: 308
• Publication Date: 2014-01-28
• Subjects: Influenza -- Periodicals; Respiratory infections -- Periodicals; Virus diseases -- Periodicals; Influenza, Human -- Periodicals; Respiratory Tract Diseases -- Periodicals; Virus Diseases -- Periodicals; Grippe -- Périodiques; Appareil respiratoire -- Infections -- Périodiques; Maladies à virus -- Périodiques; 616.203
• DOI: 10.1111/irv.12232
• Languages: English
• ISSNs: 1750-2640

Abstract

<abstract abstract-type="main" id="irv12232-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="irv12232-sec-0001" sec-type="section"> <title>Background</title> <p>Human adenovirus 55 (HAdV‐55) has caused recent outbreaks of acute respiratory disease (ARD) among adults and military trainees. The active surveillance for HAdV infections was sparse in China, and current knowledge on the HAdV‐type distributions and its molecular evolution is lacking.</p> </sec> <sec id="irv12232-sec-0002" sec-type="section"> <title>Objectives</title> <p>To acquire better understanding on the prevalence and molecular evolution of HAdV‐55 strains in China, for an informed strategy for disease control and prevention.</p> </sec> <sec id="irv12232-sec-0003" sec-type="section"> <title>Population/Methods</title> <p>Nasopharyngeal aspirates were collected from hospitalized children with ARTI in Chongqing during 2009–2012. The genotype of HAdV isolates were determined by sequencing the partial hexon and fiber genes. Whole genome sequences of HAdV‐55 were obtained for molecular evolution analysis.</p> </sec> <sec id="irv12232-sec-0004" sec-type="section"> <title>Results</title> <p>About 191 (8·55%) HAdV were detected in 2234 children, including 92 (48·2%) with HAdV‐7, 72 (37·7%) with HAdV‐3, 6 (3·1%) with HAdV‐55, 5 (2·6%) with HAdV‐5, 4 (2·1%) with HAdV‐1, 1 (0·5%) with HAdV‐2, and 11(5·8%) with untyped HAdV. Four of these children developed pneumonia, two of whom were diagnosed with severe pneumonia and/or encephalopathy. HAdV‐55 isolates clustered with HAdV‐11 sequences based on the hexon gene and clustered with HAdV‐14 sequences based on the fiber gene and the whole genome. The overall evolutionary rates of hexon gene, fiber gene, and whole genome of HAdV‐55 were estimated at 6·2 × 10<sup>−5</sup> s/s/y, 8·0 × 10<sup>−5 </sup>s/s/y, and 1·7 × 10<sup>−5</sup> s/s/y, respectively.</p> </sec> <sec id="irv12232-sec-0005" sec-type="section"> <title>Conclusions</title> <p>This study suggested HAdV‐55 as an emerging infectious disease pathogen has conserved genetic structure and is closely related to each other. Further molecular investigation based on HAdV‐55 of wider origin might facilitate understanding its diversity, dissemination, and transmission in China.</p> </sec> </abstract>