F‐18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B‐cell lymphoma. (12th February 2014)

• Record Type: Journal Article
• Authors: Gallicchio, Rosj; Mansueto, Giovanna; Simeon, Vittorio; Nardelli, Anna; Guariglia, Roberto; Capacchione, Daniela; Soscia, Ernesto; Pedicini, Piernicola; Gattozzi, Domenico; Musto, Pellegrino; Storto, Giovanni
• Is Part Of: European journal of haematology. Volume 92:Number 5(2014:May)
• Page Start: 382
• Page End: 389
• Publication Date: 2014-02-12
• Subjects: Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.12268
• Languages: English
• ISSNs: 0902-4441

Abstract

<abstract abstract-type="main" id="ejh12268-abs-0001"> <title>Abstract</title> <sec id="ejh12268-sec-0001" sec-type="section"> <title>Aim</title> <p>We evaluated the prognostic significance of standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) obtained by F‐18 FDG PET/CT (PET/CT) in patients with diffuse large B‐cell Lymphomas (DLBCL) presenting intermediate IPI score.</p> </sec> <sec id="ejh12268-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>Fifty‐two patients (61 ± 13 yr) underwent PET/CT before the first‐line chemotherapy. The mean SUVmax value, the summed MTV (cm<sup>3</sup>; 42% threshold), and the cumulative TLG (g) were registered. The patients were followed up 18 months thereafter (range 3–41 months). The PET/CT results were compared to the event‐free survival (EFS).</p> </sec> <sec id="ejh12268-sec-0003" sec-type="section"> <title>Results</title> <p>At univariate analysis, SUVmax and lactate dehydrogenase (LDH) levels were predictive, but discordantly. The Kaplan–Meier survival analysis for SUVmax showed a significant better EFS in patients presenting higher values as compared to those having lesser (<italic>P</italic> = 0.0002, HR 0.13). Summed MTV and cumulative TLG were not suitable for predicting EFS.</p> </sec> <sec id="ejh12268-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Despite the availability of new tools for the quantitative assessment of disease activity on PET/CT, the SUVmax rather than MTV and TLG remains the only predictor for EFS in DLBCL patients. The magnitude of glycolytic activity rather than the amount of metabolically active burden holds a predominant value for determining the response to chemotherapy in DLBCL.</p> </sec> </abstract>