Bortezomib and heart failure: case‐report and review of the French Pharmacovigilance database. (19th June 2013)

• Record Type: Journal Article
• Authors: Honton, Benjamin; Despas, Fabien; Dumonteil, Nicolas; Rouvellat, Caroline; Roussel, Murielle; Carrie, Didier; Galinier, Michel; Montastruc, Jean Louis; Pathak, Atul
• Is Part Of: Fundamental & clinical pharmacology. Volume 28:Number 3(2014)
• Page Start: 349
• Page End: 352
• Publication Date: 2013-06-19
• Subjects: Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/fcp.12039
• Languages: English
• ISSNs: 0767-3981

Abstract

<abstract abstract-type="main" id="fcp12039-abs-0001"> <title>Abstract</title> <p>Bortezomib is a proteasome inhibitor commonly indicated for the treatment of multiple myeloma and non Hodgkin lymphoma. Cardiac adverse drug reactions of this drug are not clearly established. We report case where direct involvement of bortezomib in the occurrence of heart failure is strongly suspected and 22 other cases spontaneously reported to the French Pharmacovigilance System. This report should increase cardiologist awareness about the risk of heart failure related to this drug. Moreover, these cases underline the need for a systematic cardiac screening in patients exposed to bortezomib.</p> </abstract>