Free‐Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues. (10th January 2014)

• Record Type: Journal Article
• Authors: Chen, Jun; Qiu, Xiaozhong; Wang, Leyu; Zhong, Wen; Kong, Jiming; Xing, Malcolm M. Q.
• Is Part Of: Advanced functional materials. Volume 24:Number 15(2014)
• Page Start: 2216
• Page End: 2223
• Publication Date: 2014-01-10
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201302949
• Languages: English
• ISSNs: 1616-301X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Current artificial tissue‐substitutes have limited clinical applications due to unmatched complex combination of cells and extracellular matrix (ECM) as seen in native tissues. From a developmental perspective, the construction of effective biomimetic tissues is from the bottom (one‐dimensional nanoparticles or two‐dimensional membranes) up (three‐dimensional scaffolds or more complex composite). In a hierarchical architecture, each sub‐structure can be assembled in a flexible way with specific regulators and cells, which overcomes the deficiency of one‐for‐all scaffold. Here, a cell‐compatible cell‐lined layered nano‐membrane is developed. Bioactive molecules are mounted on a nano‐membrane and later released to its lined cell sheet. The cell‐lined membrane is in a free‐standing form to regulate cellular functions. The major advantage of this methodology is to provide a versatile approach to construct biomimetic tissues for clinical applications.</p> </abstract>