Role of ventral subiculum in context‐induced reinstatement of heroin seeking in rats. (12th December 2012)

• Record Type: Journal Article
• Authors: Bossert, Jennifer M.; Stern, Anna L.
• Is Part Of: Addiction biology. Volume 19:Number 3(2014:May)
• Page Start: 338
• Page End: 342
• Publication Date: 2012-12-12
• Subjects: Substance abuse -- Periodicals; Substance abuse -- Physiological aspects -- Periodicals; Substance-Related Disorders -- periodicals; 616.86
• DOI: 10.1111/adb.12015
• Languages: English
• ISSNs: 1355-6215

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>In rats, reexposure to heroin‐paired contexts after extinction of lever responding in a different context reinstates heroin seeking. Previous reports indicate that ventral hippocampus/Ca1 region plays a critical role in cocaine‐, cue‐ and context‐induced reinstatement of cocaine seeking. Here, we examined whether ventral subiculum, the output region of ventral hippocampus, is involved in context‐induced reinstatement of heroin seeking. We found that reversible inactivation of ventral subiculum, but not posterior Ca1, with the gamma‐aminobutyric acid agonists muscimol + baclofen decreased context‐induced reinstatement of heroin seeking. Our findings, together with previous studies on cocaine seeking, indicate a critical role of ventral subiculum in context‐induced relapse across drug classes.</p> </abstract>