Neuroblastoma in monozygotic twins with distinct presentation pathology and outcome: Is it familial or in utero metastasis. Issue 6 (23rd December 2013)

• Record Type: Journal Article
• Authors: Abu‐Arja, Rolla; Hashem, Hasan; El‐Sheikh, Ayman; Abusin, Ghada
• Is Part Of: Pediatric blood & cancer. Volume 61:Issue 6(2014:Jun.)
• Page Start: 1124
• Page End: 1125
• Publication Date: 2013-12-23
• Subjects: Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.24906
• Languages: English
• ISSNs: 1545-5009

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="pbc24906-sec-0001" sec-type="section"> <p>To date ten sets of monozygotic twins with neuroblastoma have been reported in the literature. Twin‐to‐twin <italic>in utero</italic> metastasis have been proposed as the mechanism of tumor development in the second twin; based on similar pathology, presence of metastatic disease, absence of a primary tumor, and/or later presentation in the second twin. Hereditary neuroblastoma has not been described in this context. We propose that primary neuroblastoma can occur in monozygotic twins without twin–twin transmission; due to the different ages of presentation, histology, ploidy, and tumor behavior. Pediatr Blood Cancer 2014;61:1124–1125. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>