Synthesis of SiO2 system via sol–gel process: Biocompatibility tests with a fibroblast strain and release kinetics. Issue 6 (22nd June 2013)

• Record Type: Journal Article
• Authors: Catauro, Michelina; Bollino, Flavia; Papale, Ferdinando
• Is Part Of: Journal of biomedical materials research. Volume 102:Issue 6(2014:Aug.)
• Page Start: 1677
• Page End: 1680
• Publication Date: 2013-06-22
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.34836
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>SiO₂ glass has been synthesized via sol–gel process and enriched with 5 wt % sodium ampicillin. To verify the biocompatibility of the obtained biomaterial, fibroblasts have been grown on a glass surface and were tested for viability after 24 h. The results of the Water‐Soluble Tetrazolium (WST)‐8 analysis suggest that SiO₂ glass has an adequate biocompatibility. The amorphous nature of the gels has been ascertained by X‐ray diffraction analysis. Release kinetics have been subsequently investigated in a simulated body fluid. The amount of sodium ampicillin released has been detected by ultraviolet–visible spectroscopy. The release kinetics seems to occur in more than one stage. High‐performance liquid chromatography analysis has also been carried out to ensure the integrity of ampicillin after the synthesis treatment. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1677–1680, 2014.</p> </abstract>