Fip1 regulates mRNA alternative polyadenylation to promote stem cell self‐renewal. (4th March 2014)

• Record Type: Journal Article
• Authors: Lackford, Brad; Yao, Chengguo; Charles, Georgette M; Weng, Lingjie; Zheng, Xiaofeng; Choi, Eun‐A; Xie, Xiaohui; Wan, Ji; Xing, Yi; Freudenberg, Johannes M; Yang, Pengyi; Jothi, Raja; Hu, Guang; Shi, Yongsheng
• Is Part Of: EMBO journal. Volume 33:Number 8(2014)
• Page Start: 878
• Page End: 889
• Publication Date: 2014-03-04
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.1002/embj.201386537
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="synopsis" xml:lang="en" id="embj201386537-abs-0002"> <title>Synopsis</title> <p> <boxed-text content-type="graphic" id="embj201386537-blkfxd-0001" position="anchor" orientation="portrait"> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg5bxs6gzk" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </boxed-text> </p> <p>Alternative polyadenylation is an emerging key post‐transcriptional regulatory mechanism. The essential role for mRNA 3′ end processing factor Fip1 in stem cell self‐renewal and pluripotency reveals the importance of poly(A) site choice.</p> <p> <list id="embj201386537-list-0001" list-type="bullet"> <list-item> <p>mRNA alternative polyadenylation is critical for stem cell self‐renewal and pluripotency</p> </list-item> <list-item> <p>Fip1 is a key regulator of mRNA alternative polyadenylation</p> </list-item> <list-item> <p>The direction of alternative polyadenylation switch is controlled by Fip1 binding and the distance between alternative poly(A) sites</p> </list-item> </list> </p> </abstract>