Regeneration effect of visible light‐curing furfuryl alginate compound by release of epidermal growth factor for wound healing application. Issue 14 (16th November 2013)

• Record Type: Journal Article
• Authors: Heo, Yun; Lee, Hyung‐Jae; Kim, Eun‐Hye; Kim, Mi‐Kyung; Ito, Yoshihiro; Son, Tae‐Il
• Is Part Of: Journal of applied polymer science. Volume 131:Issue 14(2014:Jul. 15)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2013-11-16
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.40113
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>A visible light‐curable polysaccharide conjugate was prepared and was included with epidermal growth factor (EGF) for wound healing application. Alginate was modified with furfurylamine, and the furfuryl alginate (F‐alginate) was mixed with Rose Bengal for visible light reactivity. The introduction of furfuryl group was confirmed by ¹H‐NMR and UV/vis spectroscopy. Visible light‐induced crosslinking was evaluated by micropatterning and weight measurement. Swelling ratio was also determined. To verify its applicability in wound healing applications, EGF was included in the system of F‐alginate and Rose Bengal. After the confirmation of no cytotoxicity of F‐alginate and murine EGF release from the system, cell proliferation, antibacterial activity, and animal test were performed on the system. In conclusion, it was demonstrated that the system was useful for wound healing. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. <bold>2014</bold>, <italic>131</italic>, 40113.</p> </abstract>