Inside Back Cover: A Convergent Total Synthesis of the Telomerase Inhibitor (±)‐γ‐Rubromycin (Angew. Chem. Int. Ed. 17/2014). Issue 17 (1st April 2014)

• Record Type: Journal Article
• Authors: Wilsdorf, Michael; Reissig, Hans‐Ulrich
• Is Part Of: Angewandte Chemie international edition. Volume 53:Issue 17(2014)
• Page Start: 4495
• Page End: 4495
• Publication Date: 2014-04-01
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201401119
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Silicon in, silicon out could be the caption for the convergent total synthesis of the telomerase inhibitor (±)‐γ‐rubromycin reported by M. Wilsdorf and H.‐U. Reissig in their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 4332 ff.</ext-link> They combine three highly functionalized building blocks through selective organometallic chemistry and a silyl‐substituted C₃ building block plays a key role. Three acid‐promoted reactions serve to generate the sensitive spiroketal natural product under desilylation. Graphic courtesy of Dr. Daniel Trawney.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg5cg0m0m9" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>