Synthesis of Aliphatic and α‐Halogenated Ketone Cyanohydrins with the Hydroxynitrile Lyase from Manihot esculenta. Issue 4 (26th February 2014)

• Record Type: Journal Article
• Authors: Diebler, Johannes; von Langermann, Jan; Mell, Annett; Hein, Martin; Langer, Peter; Kragl, Udo
• Is Part Of: ChemCatChem. Volume 6:Issue 4(2014:Apr.)
• Page Start: 987
• Page End: 991
• Publication Date: 2014-02-26
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201300965
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The potential of the hydroxynitrile lyase from Manihot esculenta towards ketone substrates was investigated. It was observed that the length of the aliphatic chain is a key parameter for the conversion of aliphatic, non‐branched ketones. Smaller substrates are readily converted with high enantioselectivites, but the elongation of the chain length causes a significant loss in enzyme activity. For a number of halogenated, herein especially fluorinated, acetophenone derivatives the corresponding cyanohydrins have been synthesized with good to moderate enantioselectivities.</p> </abstract>