Itraconazole prophylaxis for invasive Aspergillus infection in lung transplantation. Issue 2 (5th March 2014)

• Record Type: Journal Article
• Authors: Kato, K.; Nagao, M.; Nakano, S.; Yunoki, T.; Hotta, G.; Yamamoto, M.; Matsumura, Y.; Ito, Y.; Takakura, S.; Chen, F.; Bando, T.; Matsuda, Y.; Matsubara, K.; Date, H.; Ichiyama, S.
• Is Part Of: Transplant infectious disease. Volume 16:Issue 2(2014)
• Page Start: 340
• Page End: 343
• Publication Date: 2014-03-05
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12187
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12187-abs-0001"> <title>Abstract</title> <p>Invasive <italic>Aspergillus</italic> infection (IA) is a significant cause of morbidity in lung transplantation (LT). However, its optimal prophylaxis is unclear. We routinely administer itraconazole (ITCZ) prophylaxis to all patients undergoing LT. In this study, we retrospectively evaluated the duration of prophylaxis and risk factors of IA. Among 30 adult patients who underwent LT, 5 patients developed IA. All patients with IA stopped ITCZ treatment within 1 year. At least 1 year of ITCZ prophylaxis is essential for the prevention of IA. Cytomegalovirus infection, renal replacement therapy, and tracheotomy were risk factors for IA.</p> </abstract>