Serial plasma vasopressin concentration in healthy and hospitalised neonatal foals. (11th September 2013)

• Record Type: Journal Article
• Authors: Borchers, A.; Magdesian, K. G.; Schenck, P. A.; Kass, P. H.
• Is Part Of: Equine veterinary journal. Volume 46:Number 3(2014:May)
• Page Start: 306
• Page End: 310
• Publication Date: 2013-09-11
• Subjects: Horses -- Diseases -- Periodicals; 636.108905
• DOI: 10.1111/evj.12121
• Languages: English
• ISSNs: 0425-1644

Abstract

<abstract abstract-type="main"> <title>Summary</title> <sec id="evj12121-sec-0001" sec-type="section"> <title>Reasons for performing study</title> <p>Vasopressin dysregulation occurs in critically ill human patients and in neonatal foals. Limited data about serial plasma vasopressin dynamics exist in sick neonatal foals.</p> </sec> <sec id="evj12121-sec-0002" sec-type="section"> <title>Objectives</title> <p>To evaluate serial plasma arginine vasopressin (AVP) concentrations in sick neonatal foals.</p> </sec> <sec id="evj12121-sec-0003" sec-type="section"> <title>Study design</title> <p>Prospective, longitudinal clinical study.</p> </sec> <sec id="evj12121-sec-0004" sec-type="section"> <title>Methods</title> <p>Plasma samples were collected from 7 healthy and 26 sick foals before and after initial fluid resuscitation and 12, 24, 36, 48 and 96 h after presentation. Foals with a modified sepsis score ≥11 were considered septic.</p> </sec> <sec id="evj12121-sec-0005" sec-type="section"> <title>Results</title> <p>Admission AVP was increased in septic foals compared to healthy and to sick, nonseptic foals. There were no significant differences between groups on subsequent days. Nonsurvivors had higher AVP concentrations than survivors.</p> </sec> <sec id="evj12121-sec-0006" sec-type="section"> <title>Conclusions</title> <p>Plasma AVP concentrations are higher in septic foals on admission than in healthy and sick nonseptic foals. Higher early plasma AVP concentrations are associated with increased mortality.</p> </sec> </abstract>