Discovery of a novel long terminal repeat (LTR2i_SS) in Sus Scrofa. (12th March 2014)

• Record Type: Journal Article
• Authors: Lim, Sim L.; Kortschak, R. Daniel; Adelson, David L.
• Is Part Of: Animal genetics. Volume 45:Number 3(2014:Jun.)
• Page Start: 367
• Page End: 372
• Publication Date: 2014-03-12
• Subjects: Animal genetics -- Periodicals; 572.8
• DOI: 10.1111/age.12138
• Languages: English
• ISSNs: 0268-9146

Abstract

<abstract abstract-type="main" id="age12138-abs-0001"> <title>Summary</title> <p>Long terminal repeat (LTR) retrotransposons are transposable elements flanked by 5′/3′ LTRs. They have a structure similar to endogenous retroviruses, but they lack the envelope (<italic>env</italic>) gene making them non‐infectious. Long terminal repeats are motif‐rich sequences and can act as bidirectional promoters or enhancers to regulate or inactivate genes by insertion. In this study, we identified a new chimeric LTR subfamily, LTR2i_SS, in the pig genome. This chimeric LTR family appears to be the ancestral form of the previously described LTR2_SS family. LTR2_SS appears to have deleted ~300 bp of un‐annotated, ancestral sequence from LTR2i_SS. We identified no functional provirus sequences for either of these LTR types. LTR2i_SS sequences have been exapted into the untranslated regions of two protein‐coding gene mRNAs. Both of these genes lie within previously mapped pig quantitative trait loci.</p> </abstract>