Risk of fatal cerebrovascular accidents after external beam radiation therapy for early‐stage glottic laryngeal cancer. Issue 5 (2nd July 2013)

• Record Type: Journal Article
• Authors: Swisher–McClure, Samuel; Mitra, Nandita; Lin, Alexander; Ahn, Peter; Wan, Fei; O'Malley, Bert; Weinstein, Gregory S.; Bekelman, Justin E.
• Is Part Of: Head & neck. Volume 36:Issue 5(2014:May)
• Page Start: 611
• Page End: 616
• Publication Date: 2013-07-02
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23342
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23342-sec-0001" sec-type="section"> <title>Background</title> <p>This study compared the risk of fatal cerebrovascular accidents (CVAs) in patients with early‐stage glottic laryngeal cancer receiving surgery or external beam radiation therapy (EBRT).</p> </sec> <sec id="hed23342-sec-0002" sec-type="section"> <title>Methods</title> <p>Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early‐stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database.</p> </sec> <sec id="hed23342-sec-0003" sec-type="section"> <title>Results</title> <p>The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; <italic>p</italic> = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04–2.96; <italic>p</italic> = .037).</p> </sec> <sec id="hed23342-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Treatment for early‐stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery. © 2013 Wiley Periodicals, Inc. <italic>Head Neck</italic><bold>36</bold>: 611–616, 2014</p> </sec> </abstract>