A pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder. Issue 4 (12th October 2013)

• Record Type: Journal Article
• Authors: Balodis, Iris M.; Grilo, Carlos M.; Kober, Hedy; Worhunsky, Patrick D.; White, Marney A.; Stevens, Michael C.; Pearlson, Godfrey D.; Potenza, Marc N.
• Is Part Of: International journal of eating disorders. Volume 47:Issue 4(2014:May)
• Page Start: 376
• Page End: 384
• Publication Date: 2013-10-12
• Subjects: Appetite disorders -- Periodicals; Ingestion disorders -- Periodicals; Eating disorders -- Periodicals; 616.8526
• DOI: 10.1002/eat.22204
• Languages: English
• ISSNs: 0276-3478

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="eat22204-sec-0001" sec-type="section"> <title>Objective</title> <p>The primary purpose of this study was to examine neurobiological underpinnings of reward processing that may relate to treatment outcome for binge‐eating disorder (BED).</p> </sec> <sec id="eat22204-sec-0002" sec-type="section"> <title>Method</title> <p>Prior to starting treatment, 19 obese persons seeking treatment for BED performed a monetary incentive delay task during functional magnetic resonance imaging (fMRI). Analyses examined how the neural correlates of reward processing related to binge‐eating status after 4‐months of treatment.</p> </sec> <sec id="eat22204-sec-0003" sec-type="section"> <title>Results</title> <p>Ten individuals continued to report binge‐eating (BE<sub>post‐tx</sub>) following treatment and 9 individuals did not (NBE<sub>post‐tx</sub>). The groups did not differ in body mass index. The BE<sub>post‐tx</sub> group relative to the NBE<sub>post‐tx</sub> group showed diminished recruitment of the ventral striatum and the inferior frontal gyrus during the anticipatory phase of reward processing and reduced activity in the medial prefrontal cortex during the outcome phase of reward processing.</p> </sec> <sec id="eat22204-sec-0004" sec-type="section"> <title>Discussion</title> <p>These results link brain reward circuitry to treatment outcome in BED and suggest that specific brain regions underlying reward processing may represent important therapeutic targets in BED. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:376–384)</p> </sec> </abstract>