A GENOME‐WIDE ASSOCIATION STUDY OF CLINICAL SYMPTOMS OF DISSOCIATION IN A TRAUMA‐EXPOSED SAMPLE. Issue 4 (27th March 2014)

• Record Type: Journal Article
• Authors: Wolf, Erika J.; Rasmusson, Ann M.; Mitchell, Karen S.; Logue, Mark W.; Baldwin, Clinton T.; Miller, Mark W.
• Is Part Of: Depression and anxiety. Volume 31:Issue 4(2014:Apr.)
• Page Start: 352
• Page End: 360
• Publication Date: 2014-03-27
• Subjects: Anxiety -- Periodicals; Depression, Mental -- Periodicals; Depression -- Periodicals; Anxiety -- Periodicals; Anxiety Disorders -- Periodicals; 616.8527005
• DOI: 10.1002/da.22260
• Languages: English
• ISSNs: 1091-4269

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="da22260-sec-0010" sec-type="section"> <title>Background</title> <p>Recent work suggests that a subset of individuals with posttraumatic stress disorder (PTSD) exhibit marked dissociative symptoms, as defined by derealization and depersonalization. A dissociative subtype of PTSD was added to the diagnostic criteria listed in the <italic>Diagnostic and Statistical Manual of Mental Disorders</italic>, Version 5 (<italic>DSM‐5</italic>) to capture this presentation of PTSD. This study examined genetic polymorphisms for association with the symptoms that define the dissociative subtype of PTSD using a genome‐wide approach.</p> </sec> <sec id="da22260-sec-0020" sec-type="section"> <title>Methods</title> <p>The sample comprised 484 White, non‐Hispanic, trauma‐exposed veterans and their partners who were assessed for lifetime PTSD and dissociation using a structured clinical interview. The prevalence of PTSD was 60.5%. Single‐nucleotide polymorphisms (SNPs) from across the genome were obtained from a 2.5 million SNP array.</p> </sec> <sec id="da22260-sec-0030" sec-type="section"> <title>Results</title> <p>Ten SNPs evidenced suggestive association with dissociation (<italic>P</italic> < 10<sup>−5</sup>). No SNPs met genome‐wide significance criteria (<italic>P</italic> < 5 × 10<sup>−8</sup>). The peak SNP was rs263232 (β = 1.4, <italic>P</italic> = 6.12 × 10<sup>−7</sup>), located in the adenylyl cyclase 8 (<italic>ADCY8</italic>) gene; a second SNP in the suggestive range was rs71534169 (β = 1.63, <italic>P</italic> = 3.79 × 10<sup>−6</sup>), located in the dipeptidyl‐peptidase 6 (<italic>DPP6</italic>) gene.</p> </sec> <sec id="da22260-sec-0040" sec-type="section"> <title>Conclusions</title> <p> <italic>ADCY8</italic> is integral for long‐term potentiation and synaptic plasticity and is implicated in fear‐related learning and memory and long‐term memory consolidation. <italic>DPP6</italic> is critical for synaptic integration and excitation. These genes may exert effects on basic sensory integration and cognitive processes that underlie dissociative phenomena.</p> </sec> </abstract>