CD5‐positive follicular lymphoma characterized by CD25, MUM1, low frequency of t(14;18) and poor prognosis. (March 2014)

• Record Type: Journal Article
• Authors: Miyoshi, Hiroaki; Sato, Kensaku; Yoshida, Maki; Kimura, Yoshizo; Kiyasu, Junichi; Ichikawa, Ayako; Ishibashi, Yukinao; Arakawa, Fumiko; Nakamura, Yukihiko; Nakashima, Shinji; Niino, Daisuke; Sugita, Yasuo; Ohshima, Koichi
• Is Part Of: Pathology international. Volume 64:Number 3(2014:Mar.)
• Page Start: 95
• Page End: 103
• Publication Date: 2014-03
• Subjects: Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12145
• Languages: English
• ISSNs: 1320-5463

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>CD5‐positive follicular lymphoma (FL), although rare, has been described in a number of case reports. However, a statistically valid, clinicopathological comparison between CD5‐positive FL and CD5‐negative FL has never been performed because of its rarity. We statistically compared clinicopathological characteristics of 22 cases of CD5‐positive FL, diagnosed by immunohistochemistry, flow cytometry and morphological findings, with those of 62 cases of FL without CD5 expression (control cases). CD5‐positive FL patients showed a higher tendency of peripheral blood involvement (<italic>P</italic> = 0.076) and a higher frequency of CD25 expression (<italic>P</italic> = 0.0004) and MUM1 protein expression (<italic>P</italic> = 0.0008), and a lower frequency of t(14;18)(q32;q21) (<italic>P</italic> = 0.017). The overall survival (OS) curve of CD5‐positive FL was significantly worse than that of control cases (<italic>P</italic> = 0.0266), although progression‐free survival curves did not show a significant difference (<italic>P</italic> = 0.7899). Moreover, CD5 expression was shown to be an independent poor prognostic factor for OS in both univariate analysis [Hazard Ratio (HR), 3.63; <italic>P</italic> = 0.0464] and multivariate analysis (HR, 57.16; <italic>P</italic> = 0.0001). CD5‐positive FL showed different clinicopathological characteristics from FL lacking CD5 expression. These results suggest that CD5‐positive FL should be considered a different type of FL, and its clinicopathological management should be conducted differently.</p> </abstract>