Further Antibacterial Geranium macrorrhizum L. Metabolites and Synthesis of Epoxygermacrones. Issue 4 (April 2014)

• Record Type: Journal Article
• Authors: Radulović, Niko S.; Zlatković, Dragan; Dekić, Milan; Stojanović‐Radić, Zorica
• Is Part Of: Chemistry & biodiversity. Volume 11:Issue 4(2014:Apr.)
• Page Start: 542
• Page End: 550
• Publication Date: 2014-04
• Subjects: Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201300295
• Languages: English
• ISSNs: 1612-1872

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>4, 5‐ and 1, 10‐Epoxygermacrones were isolated from the essential oil of aerial parts of <italic>Geranium macrorrhizum</italic> L. (Geraniaceae)<italic>.</italic> The structures of the epoxy derivatives were deduced from their 1D‐ and 2D‐NMR spectra, molecular modeling, and confirmed by synthesis starting from germacrone. The epoxy compounds were screened for their antimicrobial activities by a microdilution assay, which revealed high activities of both compounds against <italic>Bacillus subtilis</italic> (minimum inhibitory concentrations (<italic>M/C</italic>s) determined were 4.3 and 43 nmol/ml for 1, 10‐ and 4, 5‐epoxygermacrone, resp.) and <italic>Pseudomonas aeruginosa</italic> (0.043 and 0.855 μmol/ml for 1, 10‐ and 4, 5‐epoxygermacrone, resp.). The discovery and observed activity of the two epoxides fills the gap in our knowledge of the active principles in this highly renowned ethnomedicinal plant species.</p> </abstract>