Effectiveness of estrogen in the prevention of intrauterine adhesions after hysteroscopic septal resection: A prospective, randomized study. Issue 4 (26th February 2014)

• Record Type: Journal Article
• Authors: Roy, Kallol Kumar; Negi, Neha; Subbaiah, Murali; Kumar, Sunesh; Sharma, Jai Bhagwan; Singh, Neeta
• Is Part Of: Journal of obstetrics and gynaecology research. Volume 40:Issue 4(2014:Apr.)
• Page Start: 1085
• Page End: 1088
• Publication Date: 2014-02-26
• Subjects: Gynecology -- Periodicals; Obstetrics -- Periodicals; 618.1005
• DOI: 10.1111/jog.12297
• Languages: English
• ISSNs: 1341-8076

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jog12297-sec-0001" sec-type="section"> <title>Aim</title> <p>The aim of this prospective randomized study was to evaluate the efficacy of estrogen in preventing intrauterine adhesions following hysteroscopic septal resection and to investigate its effect on reproductive outcome.</p> </sec> <sec id="jog12297-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>After hysteroscopic septal resection, 90 women received either estrogen or placebo (<italic>n</italic> = 45 per group) for 30 days. A second‐look hysteroscopy was performed after 2 months. All pregnancies occurring during the study period were recorded.</p> </sec> <sec id="jog12297-sec-0003" sec-type="section"> <title>Results</title> <p>Adhesions developed in three of 43 (6.9%) patients in the control group compared to none in the estrogen group. This difference was not statistically significant (<italic>P</italic> = 0.24). Regarding reproductive outcome, the differences between the two groups were also not significant.</p> </sec> <sec id="jog12297-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Estrogen treatment was not found to prevent intrauterine adhesions or improve reproductive outcome after hysteroscopic septal resection.</p> </sec> </abstract>