Desmoid‐type fibromatosis of the head and neck region in the paediatric population: a clinicopathological and genetic study of seven cases. Issue 6 (30th December 2013)

• Record Type: Journal Article
• Authors: Flucke, Uta; Tops, Bastiaan B J; van, Paul J; Slootweg, Pieter J
• Is Part Of: Histopathology. Volume 64:Issue 6(2014)
• Page Start: 769
• Page End: 776
• Publication Date: 2013-12-30
• Subjects: Histology, Pathological -- Periodicals; 611.018
• DOI: 10.1111/his.12323
• Languages: English
• ISSNs: 0309-0167

Abstract

<abstract abstract-type="main" id="his12323-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="his12323-sec-0001" sec-type="section"> <title>Aims</title> <p>Desmoid‐type fibromatosis (desmoid) is a locally aggressive (myo)fibroblastic lesion. It represents one of the more common fibrous tumours in children and adolescents. The head and neck region is more often involved than in adults.</p> </sec> <sec id="his12323-sec-0002" sec-type="section"> <title>Methods and results</title> <p>We investigated the clinicopathological and genetic characteristics of seven paediatric desmoids at this anatomical site, including two cases of desmoplastic fibroma located in the mandible. There were two females and five males with an age range of 1.5–8 years. The sites of the soft tissue lesions were sinonasal (<italic>n </italic>=<italic> </italic>4) and paramandibular (<italic>n </italic>=<italic> </italic>1). All cases showed typical morphology and nuclear β‐catenin expression. <italic>CTNNB1</italic> gene sequencing, performed successfully in five cases, revealed mutations in three cases with one p.T41A (bone lesion), one p.S37A and one novel mutation, p.D32V (sinonasal soft tissue lesions). Six patients were treated by excision with positive margins in five cases. Follow‐up, available for six patients (median 4 years), showed no evidence of disease in four cases, slow progression in one case, and recurrence with stable disease in the last case.</p> </sec> <sec id="his12323-sec-0003" sec-type="section"> <title>Conclusions</title> <p>Our study provides evidence of genetic similarities in desmoid and desmoplastic fibroma. Additionally, we expanded the spectrum of mutations in <italic>CTNNB1</italic> with one novel desmoid mutation.</p> </sec> </abstract>