H2B ubiquitylation modulates spliceosome assembly and function in budding yeast. (25th February 2014)

• Record Type: Journal Article
• Authors: Hérissant, Lucas; Moehle, Erica A.; Bertaccini, Diego; Van Dorsselaer, Alain; Schaeffer‐Reiss, Christine; Guthrie, Christine; Dargemont, Catherine
• Is Part Of: Biology of the cell. Volume 106:Number 4(2014:Apr.)
• Page Start: 126
• Page End: 138
• Publication Date: 2014-02-25
• Subjects: Cytology -- Periodicals; Electron microscopy -- Periodicals; 571.6
• DOI: 10.1111/boc.201400003
• Languages: English
• ISSNs: 0248-4900

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="boc201400003-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Splicing occurs co‐transcriptionally for the vast majority of intron‐containing genes in the yeast <italic>Saccharomyces cerevisiae</italic>. Here, we analysed the contribution of transcription‐dependent chromatin marks on spliceosome assembly and function on nascent transcripts and found that multiple histone modifications, and in particular Ub‐H2B, are required for optimal spliceosome function at distinct subsets of genes. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg52wvz37c" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>