Atypical stress response to temperature and NaOCl exposure leading to septation defect during cell division in Cupriavidus metallidurans CH34. Issue 1 (19th March 2014)

• Record Type: Journal Article
• Authors: Arroua, Boussad; Bellanger, Xavier; Guilloteau, Hélène; Mathieu, Laurence; Merlin, Christophe
• Is Part Of: FEMS microbiology letters. Volume 353:Issue 1(2014:Apr.)
• Page Start: 33
• Page End: 39
• Publication Date: 2014-03-19
• Subjects: Microbiology -- Periodicals; 579
• DOI: 10.1111/1574-6968.12399
• Languages: English
• ISSNs: 0378-1097

Abstract

<abstract abstract-type="main" id="fml12399-abs-0001"> <title>Abstract</title> <p> <italic>Cupriavidus metallidurans </italic>CH34 has long been known for its temperature‐induced mutagenesis and mortality phenotype (TIMM), for which a genetic origin has been suggested repeatedly. In this report, we present microscopic‐based evidences that the TIMM process actually starts with a septation defect, leading to aberrant cell morphologies. Moreover, the septation defect of CH34 could be induced by NaOCl, thus showing that the TIMM phenotype may be part of a more general stress response. Sequence analysis of a TIMM survivor exhibiting a recurrent recognizable <italic>lysA</italic> mutation ruled out the possibility of a genetic ground linking TIMM survival and peptidoglycan synthesis.</p> </abstract>