CDKAL1 and HHEX are associated with type 2 diabetes‐related traits among Yup'ik people (在尤皮克人群中CDKAL1和HHEX与2型糖尿病相关特征有关)1. (29th October 2013)

• Record Type: Journal Article
• Authors: Klimentidis, Yann C.; Lemas, Dominick J.; Wiener, Howard H.; O'Brien, Diane M.; Havel, Peter J.; Stanhope, Kimber L.; Hopkins, Scarlett E.; Tiwari, Hemant K.; Boyer, Bert B.
• Is Part Of: Journal of diabetes. Volume 6:Number 3(2014:Jul.)
• Page Start: 251
• Page End: 259
• Publication Date: 2013-10-29
• Subjects: Diabetes -- Periodicals; 618.3646005
• DOI: 10.1111/1753-0407.12093
• Languages: English
• ISSNs: 1753-0393

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jdb12093-sec-0001" sec-type="section"> <title>Background</title> <p>Genome‐wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with type 2 diabetes (T2D), mainly among individuals of European ancestry. In the present study, we examined the frequency of these SNPs and their association with T2D‐related traits in an Alaska Native study population with a historically low prevalence of T2D. We also investigated whether dietary characteristics that may protect against T2D, such as n‐3 polyunsaturated fatty acid (PUFA) intake, modify these associations.</p> </sec> <sec id="jdb12093-sec-0002" sec-type="section"> <title>Methods</title> <p>In 1144 Yup'ik people, we examined 17 SNPs repeatedly identified in GWAS for individual and cumulative associations with T2D‐related traits. Cumulative associations were evaluated using a genetic risk score (GRS) calculated by summing risk alleles. Associations were tested for interactions with sex, body mass index (BMI), and n‐3 PUFA intake.</p> </sec> <sec id="jdb12093-sec-0003" sec-type="section"> <title>Results</title> <p>The rs7754840 SNP in <italic>CDKAL1</italic> is significantly associated with HbA1c (<italic>P</italic> = 0.00091). The rs5015480 SNP near <italic>HHEX</italic> is significantly associated (in opposite direction to that in Europeans) with a combined fasting glucose (FG) and HbA1c measure (<italic>P</italic> = 0.00046) and with homeostatic model assessment of β‐cell function (HOMA‐B; <italic>P</italic> = 0.0014). The GRS is significantly associated with FG and combined FG and HbA1c only when the <italic>HHEX</italic> SNP is dropped from the GRS. Associations are not modified by BMI or n‐3 PUFA intake.</p> </sec> <sec id="jdb12093-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our results highlight the potential importance of <italic>CDKAL1</italic> and <italic>HHEX</italic> in glucose homeostasis in this Alaska Native population with a low prevalence of T2D, and suggest that these loci should be examined in greater detail in this population.</p> </sec> </abstract>