Synthesis, Antioxidant, and Xanthine Oxidase Inhibitory Activities of 5‐[4‐[2‐(5‐Ethyl‐2‐pyridinyl)ethoxy]phenyl]methyl]‐2, 4‐thiazolidinedione Derivatives. Issue 4 (16th December 2013)

• Record Type: Journal Article
• Authors: Begum, A. Bushra; Begum, Muneera; Ranganatha, V. Lakshmi; Prashanth, T.; Zameer, Farhan; Hegdekatte, Raghavendra; Khanum, Shaukath Ara
• Is Part Of: Archiv der Pharmazie. Volume 347:Issue 4(2014:Apr.)
• Page Start: 247
• Page End: 255
• Publication Date: 2013-12-16
• Subjects: Pharmaceutical chemistry -- Periodicals; Pharmacology -- Periodicals; 615.19
• DOI: 10.1002/ardp.201300319
• Languages: English
• ISSNs: 0365-6233

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ardp201300319-sec-0001" sec-type="section"> <p>Xanthine oxidase (XO) is a complex metalloflavoprotein, the overproduction of which usually leads to a pathological condition called gout. The XO inhibitors may prove to be promising antigout agents. The XO generates superoxide anions and H₂O₂ for the self‐defense system of the organism. Abnormal production of this superoxide (reactive oxygen species) is responsible for a number of complications including inflammation, metabolic disorder, cellular aging, reperfusion damage, atherosclerosis, and carcinogenesis. In this paper, we report the synthesis of <italic>N</italic>‐substituted analogs of thiazolidinedione derivatives as effective and new class of XO inhibitors and also as antioxidant agents. Among all the compounds in the series, compound <bold>2i</bold> produced relatively better activity against human milk XO (72% inhibition), which was also supported by docking studies.</p> </sec> </abstract>