Alcohol challenge and sensitivity to change of the essential tremor rating assessment scale. Issue 4 (7th October 2013)

• Record Type: Journal Article
• Authors: Voller, Bernhard; Lines, Emily; McCrossin, Gayle; Artiles, Aaron; Tinaz, Sule; Lungu, Codrin; Hallett, Mark; Haubenberger, Dietrich
• Is Part Of: Movement disorders. Volume 29:Issue 4(2014)
• Page Start: 555
• Page End: 558
• Publication Date: 2013-10-07
• Subjects: Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.25667
• Languages: English
• ISSNs: 0885-3185

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="mds25667-sec-0001" sec-type="section"> <title>Background</title> <p>The ability of the Essential Tremor (ET) Rating Assessment Scale (TETRAS) to detect changes in tremor severity is unknown.</p> </sec> <sec id="mds25667-sec-0002" sec-type="section"> <title>Methods</title> <p>Fifteen adult ET patients received a single oral ethanol dose calculated to reach 0.05 g/dL breath alcohol content (brAC). Effects were investigated independently with accelerometry and TETRAS.</p> </sec> <sec id="mds25667-sec-0003" sec-type="section"> <title>Results</title> <p>Accelerometry data were log‐transformed and a cumulative score logACC(R+L) was calculated. Correlation between logACC(R+L) and TETRAS was significant. TETRAS and accelerometry showed a significant effect of time point using repeated‐measures analysis of variance. The difference between baseline and each of the following six time points as well as the correlation of TETRAS with brAC were significant. The calculated minimum detectable change of TETRAS was 8.9% and the effect size was d = 4.75 (95% confidence interval: 3.60–5.90).</p> </sec> <sec id="mds25667-sec-0004" sec-type="section"> <title>Conclusion</title> <p>We demonstrated sensitivity to change of the TETRAS performance scale after a therapeutic intervention, which further establishes its potential for use in both clinical and research settings. © 2013 International Parkinson and Movement Disorder Society</p> </sec> </abstract>