Synthesis of Pharmacologically Active Bis(indolyl) and Tris(indolyl) Derivatives Using Chlorotrimethylsilane. Issue 4 (20th January 2014)

• Record Type: Journal Article
• Authors: Singh, Nongthombam G.; Kathing, Chingrishon; Rani, Jims W. S.; Nongkhlaw, Rishan L.
• Is Part Of: Journal of the Chinese Chemical Society. Volume 61:Issue 4(2014:Apr.)
• Page Start: 442
• Page End: 446
• Publication Date: 2014-01-20
• Subjects: Chemistry -- Periodicals; Electronic journals; 540.5
• DOI: 10.1002/jccs.201300467
• Languages: English
• ISSNs: 0009-4536

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Chlorotrimethylsilane is found to be a comparatively fast and efficient catalyst for carrying out electrophilic substitution reactions of indoles with various aldehydes/ketones/triethylorthoformate, yielding excellent amount of bis(indolyl)methanes/tris(indolyl)methanes. The merits of this protocol are avoidance of any external energy source, minimal reaction time, simple and easy procedure and high yield under solvent free room temperature condition. The versatility of this method has been tested with various aldehydes/ketones and received satisfactory results.</p> </abstract>