Pharmacokinetic interaction between etravirine or rilpivirine and telaprevir in healthy volunteers: A randomized, two‐way crossover trial. (May 2014)

• Record Type: Journal Article
• Authors: Kakuda, Thomas N.; Leopold, Lorant; Nijs, Steven; Vandevoorde, Ann; Crauwels, Herta M.; Bertelsen, Kirk M.; Stevens, Marita; Witek, James; van Delft, Yvon; Tomaka, Frank; Hoetelmans, Richard M.W.
• Is Part Of: Journal of clinical pharmacology. Volume 54:Number 5(2014:May)
• Page Start: 563
• Page End: 573
• Publication Date: 2014-05
• Subjects: Pharmacology -- Periodicals; Pharmacology -- Periodicals; Pharmacology, Clinical -- Periodicals; 615.1
• DOI: 10.1002/jcph.245
• Languages: English
• ISSNs: 0091-2700

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jcph245-sec-0001" sec-type="section"> <p>Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) may require treatment with an HIV non‐nucleoside reverse transcriptase inhibitor (NNRTI), for example, rilpivirine or etravirine, and an HCV direct‐acting antiviral drug such as telaprevir. In a two‐panel, two‐way, crossover study, healthy volunteers were randomized to receive etravirine 200 mg twice daily ± telaprevir 750 mg every 8 hours or rilpivirine 25 mg once daily ± telaprevir 750 mg every 8 hours. Pharmacokinetic assessments were conducted for each drug at steady‐state when given alone and when coadministered; statistical analyses were least‐square means with 90% confidence intervals. Telaprevir minimum plasma concentration (C<sub>min</sub>), maximum plasma concentration (C<sub>max</sub>), and area under the concentration–time curve (AUC) decreased 25%, 10%, and 16%, respectively, when coadministered with etravirine and 11%, 3%, and 5%, respectively, when coadministered with rilpivirine. Telaprevir did not affect etravirine pharmacokinetics, but increased rilpivirine C<sub>min</sub>, C<sub>max</sub>, and AUC by 93%, 49%, and 78%, respectively. Both combinations were generally well tolerated. The small decrease in telaprevir exposure when coadministered with etravirine is unlikely to be clinically relevant. The interaction between telaprevir and rilpivirine is not likely to be clinically relevant under most circumstances. No dose adjustments are deemed necessary when they are coadministered.</p> </sec> </abstract>