Subtle retinal pathology in amyotrophic lateral sclerosis. (11th March 2014)

• Record Type: Journal Article
• Authors: Ringelstein, Marius; Albrecht, Philipp; Südmeyer, Martin; Harmel, Jens; Müller, Ann‐Kristin; Keser, Nazmiye; Finis, David; Ferrea, Stefano; Guthoff, Rainer; Schnitzler, Alfons; Hartung, Hans‐Peter; Methner, Axel; Aktas, Orhan
• Is Part Of: Annals of clinical and translational neurology. Volume 1:Number 4(2014:Apr.)
• Page Start: 290
• Page End: 297
• Publication Date: 2014-03-11
• Subjects: Nervous system -- Diseases -- Periodicals; Neurology -- Periodicals; 616.8005
• DOI: 10.1002/acn3.46
• Languages: English
• ISSNs: 2328-9503

Abstract

<abstract abstract-type="main" id="acn346-abs-0001"> <title>Abstract</title> <p>Amyotrophic lateral sclerosis (ALS) is characterized by neuro‐ophthalmological abnormalities beyond disturbed oculomotor control such as decreased visual acuity and disturbed visual evoked potentials. Here we report retinal alterations in a cohort of 24 patients with clinically definite (<italic>n</italic> = 20) or probable (<italic>n</italic> = 4) ALS as compared to matched controls. High‐resolution spectral domain optical coherence tomography with retinal segmentation revealed a subtle reduction in the macular thickness and the retinal nerve fiber layer (RNFL) as well as a marked thinning of the inner nuclear layer (INL). Our data indicate an unprecedented retinal damage pattern and suggest neurodegeneration beyond the motor system in this disease.</p> </abstract>