Absence of Intraocular Infections after Hematopoietic Stem Cell Transplantation at a Single Center: The Experience with Current Preventive Regimens. (April 2014)

• Record Type: Journal Article
• Authors: Stoyanova, Elena I.; Riemens, Anjo; Lokhorst, Henk M.; te Boome, Liane; Rothova, Aniki
• Is Part Of: Ocular immunology and inflammation. Volume 22:Number 2(2014)
• Page Start: 116
• Page End: 120
• Publication Date: 2014-04
• Subjects: Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2013.827216
• Languages: English
• ISSNs: 0927-3948

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: To investigate the prevalence of intraocular infections after allogeneic stem cell transplantation (allo-SCT).</p> <p> <italic>Methods:</italic> The study design was a single institutional retrospective noncomparative cohort of 135 consecutive patients in 2006 and 2007 who underwent allo-SCT for hematological malignancy. The primary outcome was the development of intraocular infections after allo-SCT and secondary outcome consisted of development of other ocular disorders during follow-up.</p> <p> <italic>Results</italic>: The most frequent ocular sequel to allo-SCT included ocular graft-versus-host disease (GvHD), which developed in 37/135 patients (27%). Intraocular infection occurred in 1 of 135 patients (0.7%). This patient developed infectious chorioretinitis together with osteomyelitis, endocarditis, and brain abscess with fungus <italic>Scedosporium</italic> and was successfully treated with a combination of voriconazole, amphotericine B, and surgical interventions. Viral and/or bacterial intraocular infections were not observed at all.</p> <p> <italic>Conclusions</italic>: Intraocular infections after allo-SCT are currently uncommon due to systematic use of preemptive treatment regimens, frequent controls, and early treatment of systemic infections.</p> </abstract>