Impact of weight loss on ankle‐brachial index and interartery blood pressures. (24th February 2014)

• Record Type: Journal Article
• Authors: Espeland, Mark A.; Lewis, Cora E.; Bahnson, Judy; Knowler, William C.; Regensteiner, Judith G.; Gaussoin, Sarah A.; Beavers, Daniel; Johnson, Karen C.; Brancati, Frederick L.; Swartz, Lee; Cheskin, Lawrence; Clark, Jeanne M.; Stewart, Kerry; Rubin, Richard; Arceci, Jean; Ball, Suzanne; Charleston, Jeanne; Diggins, Danielle; Johnson, Mia; Lambert, Joyce; Michalski, Kathy; Jiggetts, Dawn; Sapun, Chanchai; Bray, George A.; Rau, Kristi; Strate, Allison; Greenway, Frank L.; Ryan, Donna H.; Williamson, Donald; Armand, Brandi; Arceneaux, Jennifer; Bachand, Amy; Begnaud, Michelle; Berhard, Betsy; Caderette, Elizabeth; Cerniauskas, Barbara; Creel, David; Crow, Diane; Duncan, Crystal; Guay, Helen; Johnson, Carolyn; Jones, Lisa; Kora, Nancy; LaFleur, Kelly; Landry, Kim; Lingle, Missy; Perault, Jennifer; Puckett, Cindy; Shipp, Mandy; Smith, Marisa; Tucker, Elizabeth; MPH, Sheikilya Thomas; Safford, Monika; DiLillo, Vicki; Bragg, Charlotte; Dobelstein, Amy; Gilbert, Stacey; Glasser, Stephen; Hannum, Sara; Hubbell, Anne; Jones, Jennifer; Lee, DeLavallade; Luketic, Ruth; Oden, L. Christie; Raines, Janet; Roche, Cathy; Truman, Janet; Webb, Nita; Azuero, Casey; King, Jane; Morgan, Andre; Nathan, David M.; Cagliero, Enrico; Hayward, Kathryn; Turgeon, Heather; Delahanty, Linda; Anderson, Ellen; Bissett, Laurie; Goldman, Valerie; Harlan, Virginia; Michel, Theresa; Larkin, Mary; Stevens, Christine; Miller, Kylee; Chen, Jimmy; Blumenthal, Karen; Winning, Gail; Tsay, Rita; Cyr, Helen; Pinto, Maria; Horton, Edward S.; Jackson, Sharon D.; Hamdy, Osama; Caballero, A. Enrique; Bain, Sarah; Bovaird, Elizabeth; Fargnoli, Barbara; Spellman, Jeanne; Goebel‐Fabbri, Ann; Lambert, Lori; Ledbury, Sarah; Malloy, Maureen; Ovalle, Kerry; Blackburn, George; Mantzoros, Christos; McNamara, Ann; Spellman, Kristina; Hill, James O.; Miller, Marsha; Dorsten, Brent Van; Regensteiner, Judith; Coelho, Ligia; Cohrs, Paulette; Green, Susan; Hamilton, April; Hamilton, Jere; Leshchinskiy, Eugene; Munkwitz, Lindsey; Rome, Loretta; Worley, Terra; Craul, Kirstie; Smith, Sheila; Foreyt, John P.; Reeves, Rebecca S.; Pownall, Henry; Balasubramanyam, Ashok; Jones, Peter; Burrington, Michele; Chen, Chu‐Huang; Gardner, Allyson Clark; Gee, Molly; Griggs, Sharon; Hamilton, Michelle; Holley, Veronica; Joseph, Jayne; Palencia, Julieta; Schmidt, Jennifer; White, Carolyn; Johnson, Karen C.; Gresham, Carolyn; Connelly, Stephanie; Brewer, Amy; Coday, Mace; Jones, Lisa; Lichtermann, Lynne; Vosburg, Shirley; Taylor, J. Lee; Kitabchi, Abbas E.; Nyenwe, Ebenezer; Lambeth, Helen; Brewer, Amy; Clark, Debra; Crisler, Andrea; Force, Debra; Green, Donna; Kores, Robert; Jeffery, Robert W.; Thorson, Carolyn; Bantle, John P.; Redmon, J. Bruce; Crow, Richard S.; Crow, Scott; Raatz, Susan K; Brelje, Kerrin; Campbell, Carolyne; Carls, Jeanne; Carmean‐Mihm, Tara; Devonish, Julia; Finch, Emily; Fox, Anna; Hoelscher, Elizabeth; James, La Donna; Maddy, Vicki A.; Ockenden, Therese; Rice, Birgitta I.; Skarphol, Tricia; Tucker, Ann D.; Voeller, Mary Susan; Walcheck, Cara; Pi‐Sunyer, Xavier; Patricio, Jennifer; Heshka, Stanley; Pal, Carmen; Allen, Lynn; Chong, Lolline; Gluck, Marci; Hirsch, Diane; Holowaty, Mary Anne; Horowitz, Michelle; Rau, Nancy; Steinberg, Dori Brill; Wadden, Thomas A.; Maschak‐Carey, Barbara J; Berkowitz, Robert I.; Braunstein, Seth; Foster, Gary; Glick, Henry; Kumanyika, Shiriki; Schwartz, Stanley S.; Allen, Michael; Bell, Yuliis; Brock, Johanna; Brozena, Susan; Carvajal, Ray; Chomentowski, Helen; Crerand, Canice; Davenport, Renee; Diamond, Andrea; Fabricatore, Anthony; Goldberg, Lee; Hesson, Louise; Hudak, Thomas; Iqbal, Nayyar; Jones‐Corneille, LaShanda; Kao, Andrew; Kuehnel, Robert; Lipschutz, Patricia; Mullen, Monica; Jakicic, John M.; Wesche‐Thobaben, Jacqueline; Kuller, Lewis H.; Kriska, Andrea; Rickman, Amy D.; Yamamoto, Monica E.; Danchenko, Rebecca; Elnyczky, Barbara; Garcia, David O.; Grove, George A.; Harper, Patricia H.; Harrier, Susan; Helbling, Nicole L.; Ives, Diane; Mancino, Juliet; Mathews, Anne; Murray, Tracey Y.; Ritchea, Joan R.; Urda, Susan; Wolf, Donna L.; Wing, Rena R.; Bright, Renee; Pera, Vincent; Jakicic, John; Tate, Deborah; Gorin, Amy; Gallagher, Kara; Bach, Amy; Bancroft, Barbara; Bertorelli, Anna; Carey, Richard; Charron, Tatum; Chenot, Heather; Chula‐Maguire, Kimberley; Coward, Pamela; Cronkite, Lisa; Currin, Julie; Daly, Maureen; Egan, Caitlin; Ferguson, Erica; Foss, Linda; Gauvin, Jennifer; Kieffer, Don; Lessard, Lauren; Maier, Deborah; Massaro, JP; Monk, Tammy; Nicholson, Rob; Patterson, Erin; Phelan, Suzanne; Raynor, Hollie; Raynor, Douglas; Robinson, Natalie; Robles, Deborah; Tavares, Jane; Haffner, Steven M.; Hazuda, Helen P.; Montez, Maria G.; Lorenzo, Carlos; Coleman, Charles F.; Granado, Domingo; Hathaway, Kathy; Isaac, Juan Carlos; Ramirez, Nora; Saenz, Ronda; MB, Steven Kahn; Montgomery, Brenda; Knopp, Robert; Lipkin, Edward; Trence, Dace; Barrett, Terry; Bartell, Joli; Greenberg, Diane; Murillo, Anne; Richmond, Betty Ann; Socha, Jolanta; Thomas, April; Wesley, Alan; Bolin, Paula; Killean, Tina; Manus, Cathy; Krakoff, Jonathan; Curtis, Jeffrey M.; Glass, Justin; Michaels, Sara; Bennett, Peter H.; Morgan, Tina; Begay, Shandiin; Bloomquist, Paul; Costa, Teddy; RN, Bernadita Fallis; Hermes, Jeanette; Hollowbreast, Diane F.; Johnson, Ruby; Meacham, Maria; Nelson, Julie; Percy, Carol; Poorthunder, Patricia; Sangster, Sandra; Scurlock, Nancy; Shovestull, Leigh A.; Smiley, Janelia; Toledo, Katie; Tomchee, Christina; Tonemah, Darryl; Peters, Anne; Ruelas, Valerie; Sengardi, Siran Ghazarian; Hillstrom, Kathryn (Mandy) Graves; Konersman, Kati; Serafin‐Dokhan, Sara; Wagenknecht, Lynne E.; Bahnson, Judy L.; Reboussin, David; Rejeski, W. Jack; Bertoni, Alain G.; Lang, Wei; Lawlor, Michael S.; Lefkowitz, David; Miller, Gary D.; Reynolds, Patrick S.; Ribisl, Paul M.; Vitolins, Mara; Chen, Haiying; West, Delia S.; Friedman, Lawrence M.; Craven, Brenda L.; Dotson, Kathy M.; Hodges, Amelia; Williams, Carrie C.; Anderson, Andrea; Barnes, Jerry M.; Barr, Mary; Beavers, Daniel P.; Beckner, Tara; Davis, Cralen; Valle‐Fagan, Thania Del; Feeney, Patricia A.; Goode, Candace; Griffin, Jason; Harvin, Lea; Hogan, Patricia; King, Mark; Lane, Kathy; Neiberg, Rebecca H.; Walkup, Michael P.; Wall, Karen; Windham, Terri; Nevitt, Michael; Schwartz, Ann; Shepherd, John; Rahorst, Michaela; Palermo, Lisa; Ewing, Susan; Hayashi, Cynthia; Maeda, Jason; Marcovina, Santica M.; Chmielewski, Jessica; Gaur, Vinod; MD, Elsayed Z. Soliman; Prineas, Ronald J.; Campbell, Charles; Zhang, Zhu‐Ming; Alexander, Teresa; Keasler, Lisa; Hensley, Susan; Li, Yabing; Moran, Robert; Foushee, Richard; Hall, Nancy J.; Evans, Mary; Harrison, Barbara; Hubbard, Van S.; Yanovski, Susan Z.; Kuczmarski, Robert; Cooper, Lawton S.; Kaufman, Peter; Gregg, Edward W.; Williamson, David F.; Zhang, Ping;
• Is Part Of: Obesity. Volume 22:Number 4(2014:Apr.)
• Page Start: 1032
• Page End: 1041
• Publication Date: 2014-02-24
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20658
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20658-sec-0001" sec-type="section"> <title>Objective</title> <p>To assess whether weight loss improves markers of peripheral artery disease and vascular stenosis.</p> </sec> <sec id="oby20658-sec-0002" sec-type="section"> <title>Methods</title> <p>The Action for Health in Diabetes randomized clinical trial compared intensive lifestyle intervention (ILI) for weight loss to a control condition of diabetes support and education (DSE) in overweight or obese adults with type 2 diabetes. Annual ankle and brachial blood pressures over four years were used to compute ankle‐brachial indices (ABIs) and to assess interartery blood pressure differences in 5018 participants.</p> </sec> <sec id="oby20658-sec-0003" sec-type="section"> <title>Results</title> <p>ILI, compared to DSE, produced 7.8% (Year 1) to 3.6% (Year 4) greater weight losses. These did not affect prevalence of low (<0.90) ABI (3.60% in DSE versus 3.14% in ILI; <italic>P</italic> = 0.20) or elevated (>1.40) ABI (7.52% in DSE versus 7.59% in ILI: <italic>P</italic> = 0.90), but produced smaller mean (SE) maximum interartery systolic blood pressure differences among ankle sites [19.7 (0.2) mmHg for ILI versus 20.6 (0.2) mmHg for DSE (<italic>P</italic> < 0.001)] and between arms [5.8 (0.1) mmHg for ILI versus 6.1 (0.1) mmHg for DSE (<italic>P</italic> = 0.01)].</p> </sec> <sec id="oby20658-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Four years of intensive behavioral weight loss intervention did not significantly alter prevalence of abnormal ABI, however, it did reduce differences in systolic blood pressures among arterial sites.</p> </sec> </abstract>