Modifying effect of obesity on the association between sitting and incident diabetes in post‐menopausal women. (4th December 2013)

• Record Type: Journal Article
• Authors: Manini, Todd M.; LaMonte, Michael J.; Seguin, Rebecca A.; Manson, JoAnn E.; Hingle, Melanie; Garcia, Lorena; Stefanick, Marcia L.; Rodriguez, Beatriz; Sims, Stacy; Song, Yiqing; Limacher, Marian
• Is Part Of: Obesity. Volume 22:Number 4(2014:Apr.)
• Page Start: 1133
• Page End: 1141
• Publication Date: 2013-12-04
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20620
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20620-sec-0001" sec-type="section"> <title>Objective</title> <p>To evaluate the association between self‐reported daily sitting time and the incidence of type 2 diabetes in a cohort of postmenopausal women.</p> </sec> <sec id="oby20620-sec-0002" sec-type="section"> <title>Methods</title> <p>Women (N=88, 829) without diagnosed diabetes reported the number of hours spent sitting over a typical day. Incident cases of diabetes were identified annually by self‐reported initiation of using oral medications or insulin for diabetes > 14.4 years follow‐up.</p> </sec> <sec id="oby20620-sec-0003" sec-type="section"> <title>Results</title> <p>Each hour of sitting time was positively associated with increased risk of diabetes [risk ratio (RR): 1.05; 95% confidence interval (CI): 1.02–1.08]. However, sitting time was only positively associated with incident diabetes in obese women. Obese women reporting sitting 8–11 (RR: 1.08; 95% CI 1.0–1.1), 12–15 (OR: 1.13; 95% CI 1.0–1.2), and ≥16 hours (OR: 1.25; 95% CI 1.0–1.5) hours per day had an increased risk of diabetes compared to women sitting ≤7 hours per day. These associations were adjusted for demographics, health conditions, behaviors (smoking, diet, and alcohol intake), and family history of diabetes. Time performing moderate to vigorous intensity physical activity did not modify these associations.</p> </sec> <sec id="oby20620-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Time spent sitting was independently associated with increased risk of diabetes diagnosis among obese women—a population already at high risk of the disease.</p> </sec> </abstract>