Highly Diastereoselective and Regioselective Copper‐Catalyzed Nitrosoformate Dearomatization Reaction under Aerobic‐Oxidation Conditions. Issue 14 (3rd March 2014)

• Record Type: Journal Article
• Authors: Yang, Weibo; Huang, Long; Yu, Yang; Pflästerer, Daniel; Rominger, Frank; Hashmi, A. Stephen K.
• Is Part Of: Chemistry. Volume 20:Issue 14(2014)
• Page Start: 3927
• Page End: 3931
• Publication Date: 2014-03-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201400321
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An unprecedented copper‐catalyzed acylnitroso dearomatization reaction, which expands the traditional acylnitroso ene reaction and acylnitroso Diels–Alder reaction to a new type of transformation, has been developed under aerobic oxidation. Intermolecular and intra‐/intermolecular reaction modes demonstrate an entirely different <italic>N</italic>‐ or <italic>O</italic>‐acylnitroso selectivity. Hence, we can utilize this reaction as a highly diastereoselective access to a series of new pyrroloindoline derivatives, which are important structural motifs for natural‐product synthesis.</p> </abstract>