Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration. Issue 5 (11th June 2013)

• Record Type: Journal Article
• Authors: Pitarresi, Giovanna; Fiorica, Calogero; Palumbo, Fabio Salvatore; Rigogliuso, Salvatrice; Ghersi, Giulio; Giammona, Gaetano
• Is Part Of: Journal of biomedical materials research. Volume 102:Issue 5(2014:Jul.)
• Page Start: 1334
• Page End: 1341
• Publication Date: 2013-06-11
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/jbm.a.34818
• Languages: English
• ISSNs: 1549-3296

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>An interesting issue in tissue engineering is the development of a biodegradable vascular graft able to substitute a blood vessel and to allow its complete regeneration. Here, we report a new scaffold potentially useful as a synthetic vascular graft, produced through the electrospinning of α, β‐poly(N‐2‐hydroxyethyl) (2‐aminoethylcarbamate)‐<sc>d</sc>, <sc>l</sc>‐aspartamide‐graft‐polylactic acid (PHEA‐EDA‐<italic>g</italic>‐PLA) in the presence of polycaprolactone (PCL). The scaffold degradation profile has been evaluated as well as the possibility to bind heparin to electrospun fibers, being it a known anticoagulant molecule able to bind growth factors. <italic>In vitro</italic> cell compatibility has been investigated using human vascular endothelial cells (ECV 304) and the ability of heparinized PHEA‐EDA‐<italic>g</italic>‐PLA/PCL scaffold to retain basic fibroblast growth factor has been evaluated in comparison with not heparinized sample. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1334–1341, 2014.</p> </abstract>