Implementation of a new platelet pooling system for platelet concentrates led to a higher corrected count increment after transfusion: a comparative observational study of platelet concentrates before and after implementation. Issue 2 (10th February 2014)

• Record Type: Journal Article
• Authors: Dijkstra‐Tiekstra, M. J.; van de Watering, L. M. G.; Rondeel, J. M. M.; Slomp, J.; de Wildt‐Eggen, J.
• Is Part Of: Transfusion medicine. Volume 24:Issue 2(2014)
• Page Start: 99
• Page End: 104
• Publication Date: 2014-02-10
• Subjects: Blood -- Transfusion -- Periodicals; 615.39
• DOI: 10.1111/tme.12105
• Languages: English
• ISSNs: 0958-7578

Abstract

<abstract abstract-type="main" id="tme12105-abs-0001"> <title>SUMMARY</title> <sec id="tme12105-sec-0001" sec-type="section"> <title>Objectives</title> <p id="tme12105-para-0001">To study the effect of extended storage of platelet concentrates (PCs) and the implementation of a new platelet pooling system for PCs on corrected count increment (CCI) after transfusion.</p> </sec> <sec id="tme12105-sec-0002" sec-type="section"> <title>Background</title> <p id="tme12105-para-0002">Due to new developments and changes in processes or procedures, one should remain alert for the effects of these changes. Besides <italic>in vitro</italic> studies and validation, <italic>in vivo</italic> studies are also important, as it has been shown that <italic>in vitro</italic> results do not always predict <italic>in vivo</italic> outcomes.</p> </sec> <sec id="tme12105-sec-0003" sec-type="section"> <title>Methods/Materials</title> <p id="tme12105-para-0003">After introduction of extended storage of PCs for 5–7 days prepared from five buffy coats and plasma, transfusion monitoring for transfusions of PCs in haemato‐oncological patients was set up. After 9 months, a new pooling system for PCs was implemented, Composelect instead of Optipure PLT, and transfusion monitoring was continued for another 8 months. The CCI was used as primary outcome.</p> </sec> <sec id="tme12105-sec-0004" sec-type="section"> <title>Results</title> <p id="tme12105-para-0004">In total, 93 patients were included and transfused with PCs prepared in the Optipure PLT system (262 transfusions) or in the Composelect system (127 transfusions). Extended storage of PCs for 7 days had no significant effect on CCI. Although the implementation of the Composelect system did not influence the CCI<sub>1 h</sub> (13·8 ± 6·0 vs 13·0 ± 5·8; n.s.), it seemed to have a positive effect on CCI<sub>24 h</sub> (7·0 ± 4·9 vs 4·7 ± 4·5; <italic>P</italic> < 0·05).</p> </sec> <sec id="tme12105-sec-0005" sec-type="section"> <title>Conclusion</title> <p id="tme12105-para-0005">Although the influence of confounders could not be excluded, it seemed that implementation of the Composelect system for PCs led to an improved CCI<sub>24 h</sub> and that extended storage of PCs did not influence the CCI.</p> </sec> </abstract>