Antitags: SERS‐Encoded Nanoparticle Assemblies that Enable Single‐Spot Multiplex Protein Detection. (16th December 2013)

• Record Type: Journal Article
• Authors: Guarrotxena, Nekane; Bazan, Guillermo C.
• Is Part Of: Advanced materials. Volume 26:Number 12(2014)
• Page Start: 1941
• Page End: 1946
• Publication Date: 2013-12-16
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201304107
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201304107-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Simultaneous detection of multiple proteins on a single spot</bold> can be efficiently achieved by using multiplexed surface‐enhanced Raman spectroscopy (SERS)‐encoded nanoparticle 'antitags' consisting of poly(ethylene glycol) (PEG)‐protected silver dimers (and higher aggregates) and antibody‐tagging entities. The effective SERS‐based multivariate deconvolution approach guarantees an accurate and successful distinguishable identification of single and multiple proteins in complex samples. Their potential application in multiplexed SERS bioimaging technology can be easily envisaged. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4xfgjnh3" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>