Inside Cover: Allosteric Indicator Displacement Enzyme Assay for a Cyanogenic Glycoside (Chem. Eur. J. 43/2013). Issue 43 (14th October 2013)

• Record Type: Journal Article
• Authors: Jose, D. Amilan; Elstner, Martin; Schiller, Alexander
• Is Part Of: Chemistry. Volume 19:Issue 43(2013)
• Page Start: 14326
• Page End: 14326
• Publication Date: 2013-10-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201390170
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Toxic cyanogenic glycosides </bold> can be found in bitter almonds and apricots pits. A chemical biosensor for the selective detection of amygdalin in aqueous solution is reported by A. Schiller et al. in their Full Paper on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 14451 ff.</ext-link> The hybrid sensor consists of the enzyme β‐glucosidase and a boronic acid appended viologen together with a fluorescent reporter dye. β‐Glucosidase degrades the amygdalin into hydrogen cyanide, glucose and benzaldehyde. Only the released cyanide binds at the allosteric site of the boronic acid.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3tpf0v" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>