Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation. Issue 52 (21st November 2013)

• Record Type: Journal Article
• Authors: Serizawa, Hiroki; Aikawa, Kohsuke; Mikami, Koichi
• Is Part Of: Chemistry. Volume 19:Issue 52(2013)
• Page Start: 17692
• Page End: 17697
• Publication Date: 2013-11-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201303828
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Being economic with fluorine</bold>: The direct synthesis of CuCF₃ from a cuprate reagent and trifluoromethyl ketones, as one of the most economical and efficient trifluoromethyl sources, was accomplished. The advantages of this method are all of reagents employed are low‐cost, operation is simple, and the yield of CuCF₃ is virtually quantitative (see scheme). Furthermore, three types of trifluoromethylations smoothly proceeded to provide the corresponding products in high yields.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3stqxc" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>