Exocyclic Control of Turn Induction in Macrocyclic Peptide Scaffolds. Issue 52 (20th November 2013) - Zaretsky, Serge
Abstract Modification of a peptide: The combination of aziridine aldehyde based peptide cyclization and aziridine ring‐opening chemistry furnishes peptides with well‐defined secondary structure. An exocyclic amide, which is a product of the cyclization reaction, forms a number of intramolecular hydrogen bonds, thereby leading to increased scaffold rigidity and cellular permeability (see scheme).