Fast and Efficient 18F‐Labeling by [18F]Fluorophenylazocarboxylic Esters. Issue 2 (11th December 2013)

• Record Type: Journal Article
• Authors: Fehler, Stefanie K.; Maschauer, Simone; Höfling, Sarah B.; Bartuschat, Amelie L.; Tschammer, Nuska; Hübner, Harald; Gmeiner, Peter; Prante, Olaf; Heinrich, Markus R.
• Is Part Of: Chemistry. Volume 20:Issue 2(2014)
• Page Start: 370
• Page End: 375
• Publication Date: 2013-12-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201303409
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Introduction of [¹⁸F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30 seconds, with radiochemical yields of up to 95 % (85(±10) %). For labeling purposes, the resulting ¹⁸F‐substituted azoester can be further converted in radical‐arylation reactions to give biaryls, or in substitutions at its carbonyl unit to produce azocarboxamides.</p> </abstract>