Highly Enantioselective Decarboxylative Mannich Reaction of Malonic Acid Half Oxyesters with Cyclic Trifluoromethyl Ketimines: Synthesis of β‐Amino Esters and Anti‐HIV Drug DPC 083. Issue 47 (21st October 2013)

• Record Type: Journal Article
• Authors: Yuan, Hai‐Na; Li, Shen; Nie, Jing; Zheng, Yan; Ma, Jun‐An
• Is Part Of: Chemistry. Volume 19:Issue 47(2013)
• Page Start: 15856
• Page End: 15860
• Publication Date: 2013-10-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201303307
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>An organocatalytic enantioselective</bold> decarboxylative Mannich reaction of malonic acid half oxyesters with cyclic ketimines was developed for the preparation of enantioenriched β‐amino esters with a quaternary stereogenic center and the anti‐HIV drug DPC 083 (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7pjjtk" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>