Visible‐Light‐Induced Radical Cyclization of Trifluoroacetimidoyl Chlorides with Alkynes: Catalytic Synthesis of 2‐Trifluoromethyl Quinolines. Issue 50 (5th November 2013)

• Record Type: Journal Article
• Authors: Dong, Xichang; Xu, Youwei; Liu, Jing Jing; Hu, Yumin; Xiao, Tiebo; Zhou, Lei
• Is Part Of: Chemistry. Volume 19:Issue 50(2013)
• Page Start: 16928
• Page End: 16933
• Publication Date: 2013-11-05
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201303149
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A simple and efficient method</bold> for the synthesis of 2‐trifluoromethyl quinolines by means of visible‐light‐induced radical cyclization of trifluoroacetimidoyl chlorides with alkynes has been developed. This protocol allows the generation of imidoyl radicals by activation of C(sp²)Cl bonds using a photoredox catalyst under mild and environmentally friendly conditions (see scheme).<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t3t0tjq" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>