"On Water", Phosphine‐Free Palladium‐Catalyzed Room Temperature CH Arylation of Indoles. Issue 45 (7th October 2013)

• Record Type: Journal Article
• Authors: Islam, Saidul; Larrosa, Igor
• Is Part Of: Chemistry. Volume 19:Issue 45(2013)
• Page Start: 15093
• Page End: 15096
• Publication Date: 2013-10-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201302838
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Get on top of your chemistry!</bold> An "on water", palladium‐catalyzed, phosphine‐free direct CH arylation of indoles, with iodoarenes at 25–30 °C, is disclosed (see scheme; TBDMS=<italic>N</italic>‐<italic>tert</italic>‐butyldimethylsilyl ether; SEM=<italic>N</italic>‐2‐(trimethylsilyl)ethoxymethyl; Bn=benzyl, Piv=pivabyl). The mildness of the reaction conditions permits the tolerance of a variety of N1<italic>‐</italic>protected indoles.<boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg4t7ndgjr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>