Programmed Self‐Assembly of a Quadruplex DNA Nanowire. Issue 13 (25th February 2014)

• Record Type: Journal Article
• Authors: Ma'ani Hessari, Nason; Spindler, Lea; Troha, Tinkara; Lam, Wan‐Chi; Drevenšek‐Olenik, Irena; Webba da Silva, Mateus
• Is Part Of: Chemistry. Volume 20:Issue 13(2014)
• Page Start: 3626
• Page End: 3630
• Publication Date: 2014-02-25
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201300692
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The ability to produce, reproducibly and systematically, well‐defined quadruplex DNA nanowires through controlled rational design is poorly understood despite potential utility in structural nanotechnology. The programmed hierarchical self‐assembly of a long four‐stranded DNA nanowire through cohesive self‐assembly of GpC and CpG "sticky" ends is reported. The encoding of bases within the quadruplex stem allows for an uninterrupted π‐stacking system with rectilinear propagation for hundreds of nanometers in length. The wire is mechanically stable and features superior nuclease resistance to double‐stranded DNA. The study indicates the feasibility for programmed assembly of uninterrupted quadruplex DNA nanowires. This is fundamental to the systematic investigation of well‐defined DNA nanostructures for uses in optoelectronic and electronic devices as well as other structural nanotechnology applications.</p> </abstract>