An Artificial Imine Reductase based on the Ribonuclease S Scaffold. Issue 3 (3rd February 2014)

• Record Type: Journal Article
• Authors: Genz, Maika; Köhler, Valentin; Krauss, Michel; Singer, David; Hoffmann, Ralf; Ward, Thomas R.; Sträter, Norbert
• Is Part Of: ChemCatChem. Volume 6:Issue 3(2014:Mar.)
• Page Start: 736
• Page End: 740
• Publication Date: 2014-02-03
• Subjects: Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201300995
• Languages: English
• ISSNs: 1867-3880

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Dative anchoring of a piano‐stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S‐peptide. Binding of Cp*Ir (Cp*=C₅Me₅) to the native active site resulted in good conversions and moderate enantiomeric excess values for the synthesis of salsolidine.</p> </abstract>